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Decoding cortical chronotopy-Comparing the influence of different cortical organizational schemes
Falko Mecklenbrauck1, Jorge Sepulcre2, Jana Fehring3
1Department of Psychology, Biological Psychology, University of Münster, Germany; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Germany.
Neuroimage
|November 4, 2024
Summary
The brain
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Brain Imaging
Background:
- The brain processes stimuli across diverse temporal scales.
- Understanding the neural basis of these intrinsic timescales is crucial for comprehending sensory perception.
- Cortical organization plays a key role in temporal processing.
Purpose of the Study:
- To identify cortical organizational schemes that explain variations in intrinsic brain timescales.
- To investigate the neural architecture supporting the processing of stimuli with different temporal persistency.
- To determine which organizational scheme best explains temporal processing during rest and task conditions.
Main Methods:
- Collected resting-state fMRI, task-fMRI, and diffusion-weighted imaging data from 47 individuals.
- Extracted six cortical organizational schemes: structural Rich Club, structural Diverse Club, functional uni-to-multimodal gradient, spatial posterior/lateral-to-anterior/medial gradient, structural centrality, and cytoarchitectural differences.
- Employed Bayesian model comparison to assess the impact of these schemes on intrinsic timescales and task-based inter-subject correlation (ISC).
Main Results:
- Slower intrinsic timescales were observed in structural network hubs, hierarchically higher areas (defined by functional and spatial gradients), and thicker cortical regions.
- Inter-subject correlation (ISC) analysis suggested that higher cortical areas are engaged with more temporally persistent stimuli.
- Bayesian model comparison identified the functional uni-to-multimodal gradient as the most effective scheme for explaining chronotopy in both resting-state and task conditions.
Conclusions:
- The functional uni-to-multimodal gradient is a key organizational principle shaping the brain's temporal processing.
- This gradient influences both intrinsic brain timescales and the processing of temporally complex tasks.
- Further research into microarchitectural features underlying this gradient is warranted to understand brain adaptation and evolution in processing.
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