Serum albumin nadir as marker of inflammatory response in abdominal trauma

Serum albumin levels decrease following major trauma, for various reasons. We postulated that the serum albumin nadir (SAN) level would correlate negatively with severity of physiological insult.

This retrospective cohort study included all patients with abdominal trauma admitted to the Trauma Intensive Care Unit at Inkosi Albert Luthuli Central Hospital during 2017 and 2018.

Of the 87 patients, 70 (80.5%) were male. Mean age was 32.48 years (SD 11.65; range 12-73). Blunt trauma comprised 54 patients (62.1%). Median SAN level was 23 g/L (IQR 20-27; range 10-38). Median SAN level was not different between patients with blunt versus penetrating trauma (p = 0.69), patients in whom inotropic support had been used/not used (p = 0.0502), and no different between patients on the various modes of feeding at the time of SAN (p = 0.14). However, median SAN level was lower for patients with hollow visceral injury (p = 0.004), for patients who had undergone laparotomy (p = 0.0006), for those who had received damage control surgery (p = 0.001), those who had received blood transfusions (p = 0.03), and patients who died compared to survivors (p = 0.02). Univariate regression analysis revealed negative coefficients for the following in relation to SAN level: blood transfusion (-2.77; p = 0.023), hollow viscus injury (-3.21; p = 0.008), laparotomy (-4.5; p < 0.001), damage control surgery (-3.60; p = 0.02), day of SAN (-0.39; p = 0.001), ICU length of stay (-0.12; p = 0.002), and death (-3.27; p = 0.03).

Greater physiological insults lead to lower levels of SAN. Serum albumin nadir level may therefore have value as a prognostic indicator in the acute trauma setting.