Fibre-specific white matter changes in anorexia nervosa
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Fixel-based analysis (FBA) reveals white matter (WM) atrophy in the anterior corona radiata and corpus callosum in anorexia nervosa (AN) patients, findings missed by traditional diffusion tensor imaging (DTI). This suggests myelin loss contributes to AN symptomatology.
Area Of Science
- Neuroimaging
- Neuroscience
- Psychiatry
Background
- White matter (WM) abnormalities are documented in anorexia nervosa (AN).
- Previous studies predominantly used diffusion tensor imaging (DTI), which has limitations in resolving complex fiber arrangements.
- Fixel-based analysis (FBA) offers enhanced anatomical specificity and interpretability for WM abnormalities.
Purpose Of The Study
- To investigate fiber-specific WM abnormalities in acute AN using FBA.
- To compare FBA findings with traditional DTI metrics in AN patients.
- To identify brain regions and potential pathological mechanisms underlying AN.
Main Methods
- Diffusion-weighted imaging scans were acquired from 26 acute AN patients and 31 healthy controls.
- Fixel-based analysis (FBA) was employed to assess WM integrity.
- Diffusion tensor imaging (DTI) metrics were also calculated and compared between groups.
Main Results
- FBA identified significant reductions in fiber-bundle cross-section in the anterior corona radiata and genu of the corpus callosum in AN patients, indicating morphological atrophy.
- These affected tracts connect brain regions implicated in AN symptomatology.
- DTI revealed increased axial diffusivity in the cerebellar peduncles of AN patients, with no significant differences in other DTI metrics. No overlap was found between FBA and DTI findings.
Conclusions
- FBA is a powerful tool for detecting WM abnormalities in AN that may be missed by DTI.
- Morphological atrophy in specific WM tracts, particularly the anterior corona radiata and genu of the corpus callosum, is evident in AN.
- Myelin loss is suggested as a contributing factor to the observed WM abnormalities and clinical presentation in AN.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...