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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329

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Strategies to develop polymeric microneedles for controlled drug release.

Bo Zhi Chen1, Yu Ting He2, Ze Qiang Zhao2

  • 1State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China; Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China; Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, Japan.

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Microneedle controlled-release systems offer minimally invasive, spatiotemporally controlled drug delivery. Innovations in polymeric microneedle design enhance drug release precision for next-generation therapies.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Microneedle (MN) systems are gaining traction for drug delivery due to their minimally invasive nature and potential for controlled release.
  • Advancements focus on material properties, MN design, and external device integration for spatiotemporal control.
  • Understanding drug release mechanisms (diffusion, swelling, degradation, triggering, targeting) is crucial.

Purpose of the Study:

  • To critically review design strategies for polymeric microneedle systems enabling temporally controlled and locally targeted drug release.
  • To examine drug release mechanisms from polymeric microneedles.
  • To discuss the potential and challenges of translating these systems into advanced therapies.

Main Methods:

  • Literature review of microneedle system design strategies.
  • Analysis of drug release mechanisms from polymeric microneedles.
  • Discussion of current research and future perspectives.

Main Results:

  • Polymeric microneedle systems can be designed for precise spatiotemporal drug release.
  • Various mechanisms govern drug release, offering tunable profiles.
  • Innovative designs are expanding the capabilities of microneedle drug delivery.

Conclusions:

  • Microneedle technology holds significant promise for developing next-generation therapies with enhanced drug delivery control.
  • Further research into design and translation is needed to overcome existing challenges.
  • The field is rapidly evolving, offering new avenues for targeted and controlled therapeutic interventions.