Related Experiment Video

Updated: Jun 8, 2025

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
09:51

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Published on: January 27, 2023

1.6K

Targeting uridine diphosphate glucuronosyltransferase 1A1 in liver disease: Current research and future directions

Seok-Chan Park1, Yu Ji Kim2, Jong-Won Kim3

  • 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.

World Journal of Gastroenterology
|November 4, 2024
PubMed

Insights

Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) can prevent liver injury progression. UGT1A1 mitigates liver damage by reducing stress and metabolic dysfunction, thereby preventing cell death.

Area of Science:

  • Hepatology
  • Molecular Biology
  • Biochemistry

Background:

  • Liver injury involves endoplasmic reticulum stress, oxidative stress, and lipid metabolism.
  • Hepatocyte apoptosis and necroptosis are key features of liver damage.

Discussion:

  • Increased UGT1A1 levels during liver injury show protective effects.
  • UGT1A1 may mitigate liver damage by targeting key stress pathways.

Key Insights:

  • UGT1A1 plays a crucial role in preventing the progression of liver injury.
  • Reducing endoplasmic reticulum stress, oxidative stress, and lipid dysregulation are mechanisms by which UGT1A1 protects hepatocytes.
  • UGT1A1 impedes hepatocyte apoptosis and necroptosis, crucial for liver regeneration.

Outlook:

  • Further research into UGT1A1's therapeutic potential for liver diseases is warranted.
  • Targeting UGT1A1 could offer novel strategies for managing liver injury.
Keywords:
Endoplasmic reticulum stressLipid metabolism disordersLiver injuryOxidative stressUridine diphosphate glucuronosyltransferase 1A1

More Related Videos

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

7.8K
Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery12:40

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

10.2K

Related Concept Videos

Phase II Reactions: Glucuronidation01:24

Phase II Reactions: Glucuronidation

Glucuronidation, a pivotal phase II biotransformation process, involves the coupling of glucuronic acid to a drug or xenobiotic. Given its widespread occurrence and critical role in drug metabolism, it's considered the most crucial phase II reaction. It enhances the water solubility of substances, aiding their expulsion from the body. The driving force behind these reactions is a group of enzymes known as UDP-glucuronosyltransferases (UGTs). UGTs facilitate the transfer of a glucuronic acid...
305
Drug Metabolism: Phase II Reactions01:14

Drug Metabolism: Phase II Reactions

Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...
3.7K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
6.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K