Functional correlates of executive dysfunction in primary progressive aphasia: a systematic review
Kristin Thomsen1,2, Stefanie Keulen2,3, Seçkin Arslan1
1Université Côte d'Azur, CNRS, BCL, Nice, France.
Frontiers in Aging Neuroscience
|November 4, 2024
Summary
Neurophysiological markers like MEG and PET reveal executive dysfunction in Primary Progressive Aphasia (PPA). These markers, including brain activity and metabolism changes, aid in assessing executive function (EF) deficits in PPA patients.
Area of Science:
- Neuroscience
- Neurology
- Cognitive Science
Background:
- Executive dysfunction is increasingly recognized as a key feature of Primary Progressive Aphasia (PPA).
- Understanding the neurophysiological underpinnings of executive function (EF) deficits in PPA is crucial for accurate assessment and management.
- Existing research on neurophysiological markers for EF in PPA is limited.
Purpose of the Study:
- To systematically review neurophysiological markers associated with executive function deficits in PPA.
- To evaluate the effectiveness of functional markers in assessing executive function (EF) impairments in PPA.
- To explore the relationship between neurophysiological findings and executive dysfunction in PPA.
Main Methods:
- Systematic literature search conducted following PRISMA guidelines.
- Inclusion of studies utilizing neuropsychological assessments and neurophysiological imaging techniques (EEG, MEG, PET, SPECT, fMRI, fNIRS).
- Synthesis of findings from nine articles involving 111 individuals with PPA.
Main Results:
- Magnetoencephalography (MEG) studies indicated widespread oscillatory slowing (increased delta, decreased alpha power) predicting EF deficits.
- Positron Emission Tomography (PET) findings showed correlations between executive dysfunction and frontal hypometabolism.
- Functional Magnetic Resonance Imaging (fMRI) revealed elevated homotopic connectivity and abnormal hippocampal connections associated with reduced executive performance.
Conclusions:
- Neurophysiological tools, such as MEG and PET, can effectively aid in evaluating executive function (EF) deficits in PPA.
- Findings support the significance of frontal regions and the inferior frontal junction in executive control.
- This review highlights the potential for neurophysiological markers to deepen the understanding of clinical-neurophysiological correlations in PPA.
Keywords:
MEGPETexecutive functionsfMRIneurophysiological imagingneuropsychologyprimary progressive aphasiaMore Related Videos
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