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Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With COVID-19 Infection in Morocco

Naima Amenzoui1,2, Siham Zouiter1,2, Meriem Nassid1

  • 1Clinical Immunology and Infectious Pediatrics Department, Abderrahim Harouchi Mother and Childrens Hospital, Casablanca, Morocco.

Global Pediatric Health
|November 4, 2024
PubMed

Insights

This study describes the clinical features of Multisystem Inflammatory Syndrome in Children (MIS-C) in Morocco. Findings align with global data, highlighting fever, respiratory, and gastrointestinal symptoms in affected pediatric patients.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Rheumatology

Background:

  • Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but serious condition following viral infections.
  • Understanding the clinical spectrum of MIS-C is crucial for timely diagnosis and management.
  • Previous studies have documented MIS-C globally, but regional data is essential.

Purpose of the Study:

  • To characterize the clinical and paraclinical features of MIS-C in a Moroccan pediatric cohort.
  • To compare these findings with existing international literature on MIS-C.
  • To provide insights into the presentation and treatment of MIS-C in North Africa.

Main Methods:

  • Retrospective study of 52 children diagnosed with MIS-C.
  • Data collected over a 3-year period at Abderrahim Harrouchi Hospital, Morocco.
  • Diagnosis based on World Health Organization (WHO) criteria.

Main Results:

  • Median age of affected children was 6 years (IQR: 1-14).
  • Fever was universal (100%), with frequent respiratory (58%) and gastrointestinal (44%) symptoms.
  • Myocarditis occurred in 12% of cases; shock in 17%.
  • All patients received intravenous immunoglobulin and methylprednisolone.

Conclusions:

  • The clinical profile of MIS-C in this Moroccan cohort mirrors international observations.
  • Fever, respiratory, and gastrointestinal symptoms are key indicators.
  • Further research is warranted to validate these findings and inform regional guidelines.

Keywords:
COVID-19MIS-Cchildren

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