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Published on: July 3, 2018
Circulating miRNA-106b-5p As a Potential Biomarker for Coronary Artery Disease
Rosita Azar Bahadori1, Dina Shabani2, Elham Arjmandrad3
1Department of Molecular Genetics, Parand Branch, Islamic Azad University, Tehran, Iran.
Insights
Researchers identified miR-106b-5p as a potential biomarker for early diagnosis of coronary artery diseases (CAD). This microRNA showed significantly elevated expression in CAD patients, suggesting its utility in clinical detection.
Area of Science:
- Cardiovascular Research
- Molecular Biology
- Biomarker Discovery
Background:
- Coronary artery diseases (CAD) are a leading cause of global mortality.
- Early diagnosis of CAD is crucial for effective management.
- MicroRNAs (miRNAs) are increasingly recognized for their role in various diseases, including CAD.
Purpose of the Study:
- To identify specific microRNAs (miRNAs) for the early detection of coronary artery diseases (CAD).
- To investigate the potential of selected miRNAs as diagnostic biomarkers for CAD.
Main Methods:
- Analysis of a CAD patient dataset (GSE113079) to identify differentially expressed messenger RNAs (DEmRNAs).
- Computational prediction to select miRNAs with significant interactions with DEmRNAs.
- Assessment of miRNA expression levels in CAD patients versus healthy controls.
Main Results:
- Five miRNAs (miR-106b-5p, miR-20a-3p, miR-17-3p, miR-146a-5p, miR-155-3p) were computationally selected based on their interaction with DEmRNAs.
- A statistically significant elevation in miR-106b-5p expression was observed exclusively in the CAD patient group compared to the healthy control group (p>0.001).
Conclusions:
- The study identified an elevated expression of miR-106b-5p in individuals with coronary artery diseases.
- miR-106b-5p shows promise as a potential diagnostic biomarker for early CAD detection.
- Further research is warranted to validate these findings and confirm the clinical utility of miR-106b-5p.
Abstract:
Coronary artery diseases (CAD) represent a significant global health concern and are recognized as a primary contributor to mortality on a worldwide scale. Early diagnosis of CAD is one of promising goal to manage this disorder. Recent investigations have highlighted the pivotal involvement of microRNAs (miRNAs) in diverse health conditions, notably CAD. The principal objective of this investigation was to identify appropriate miRNAs that could be employed for the early detection of CAD. In the present study, we analyzed dataset of CAD (GSE113079) and 100 differentially expressed mRNAs (DEmRNAs) were detected. The miRNAs that have a significant interaction with DEmRNAs were chosen. By computational prediction method, 5 miRNAs (miR-106b-5p, miR-20a-3p, miR-17-3p, miR-146a-5p, and miR-155-3p) were selected. Finally, we assessed the anticipated expression levels of microRNAs in CAD patients and healthy control groups. Our findings revealed a statistically significant elevation solely in the expression level of miR-106b-5p within the CAD group when compared to the control group (p>0.001). Our study demonstrated an elevation in the expression of miR-106b-5p in individuals diagnosed with CAD. This microRNA may be used as a diagnostic biomarker in patients with CAD. However, further investigations are needed to confirm these results.
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