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Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Related Experiment Video

Updated: Jun 8, 2025

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Primary Refractory Discordant Diffuse Large B-Cell and Classical Hodgkin Lymphoma.

Yuxin Bai1,2, Samantha Bolger1,2, Sahar Khan1,3

  • 1Schulich School of Medicine and Dentistry, London, ON, Canada.

Journal of Hematology
|November 4, 2024
PubMed
Summary

Discordant lymphomas, rare conditions with two distinct lymphomas in one patient, pose diagnostic challenges. This case highlights a novel immune checkpoint inhibitor strategy for refractory large B-cell and classic Hodgkin lymphoma.

Area of Science:

  • Oncology
  • Hematology
  • Pathology

Background:

  • Discordant lymphomas involve multiple distinct lymphomas in a single patient, a rare occurrence.
Keywords:
Checkpoint inhibitorClassical Hodgkin lymphomaDiscordant lymphomaLarge B-cell lymphoma

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  • Diagnosis is challenging due to rarity, leading to limited literature and treatment guidelines.
  • Primary refractory large B-cell lymphoma and classic Hodgkin lymphoma represent a complex discordant presentation.