Related Experiment Video
Updated: Jun 8, 2025

Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
Primary Refractory Discordant Diffuse Large B-Cell and Classical Hodgkin Lymphoma.
Yuxin Bai1,2, Samantha Bolger1,2, Sahar Khan1,3
1Schulich School of Medicine and Dentistry, London, ON, Canada.
Discordant lymphomas, rare conditions with two distinct lymphomas in one patient, pose diagnostic challenges. This case highlights a novel immune checkpoint inhibitor strategy for refractory large B-cell and classic Hodgkin lymphoma.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Discordant lymphomas involve multiple distinct lymphomas in a single patient, a rare occurrence.
- Diagnosis is challenging due to rarity, leading to limited literature and treatment guidelines.
- Primary refractory large B-cell lymphoma and classic Hodgkin lymphoma represent a complex discordant presentation.
More Related Videos
15:07VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
08:53Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Related Concept Videos
Cells of the Adaptive Immune Response
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Diversity of Antigen Receptors
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...