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Accuracy of Diagnosing Optic Neuritis Using DANTE T1-SPACE Imaging.

Ayaka Shimada1,2, Kenji Suda1, Eri Nakano1

  • 1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Eye and Brain
|November 4, 2024
PubMed
Summary

Delay alternating with nutation for tailored excitation (DANTE) T1-SPACE imaging demonstrates superior sensitivity for diagnosing optic neuritis compared to other MRI sequences. This advanced MRI technique correlates with clinical findings, aiding in diagnosis and treatment assessment.

Keywords:
Optic neuritismagnetic resonance imagingretinal nerve fiber layervisual field test

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Area of Science:

  • Ophthalmology
  • Radiology
  • Neuroscience

Background:

  • Optic neuritis diagnosis can be challenging, requiring sensitive imaging techniques.
  • Magnetic Resonance Imaging (MRI) plays a crucial role in evaluating optic nerve inflammation.

Purpose of the Study:

  • To evaluate the diagnostic utility of DANTE T1-SPACE MRI for optic neuritis.
  • To compare DANTE T1-SPACE with other MRI sequences (VIBE, STIR).
  • To analyze the correlation between DANTE T1-SPACE findings and clinical parameters.

Main Methods:

  • Retrospective analysis of 36 eyes from 30 patients with optic neuritis or NA-AION.
  • MRI scans included post-contrast DANTE T1-SPACE, VIBE, and STIR sequences.
  • Independent review of MRI scans by three ophthalmologists.

Main Results:

  • DANTE T1-SPACE showed significantly higher sensitivity (100%) for optic neuritis detection than STIR (67%, p=0.009).
  • VIBE imaging did not consistently confirm enhancement in optic neuritis lesions.
  • DANTE T1-SPACE lesion length correlated with retinal nerve fiber layer thickness, eye pain, and symptom-to-MRI interval.

Conclusions:

  • Contrast-enhanced DANTE T1-SPACE is a more sensitive MRI sequence for diagnosing optic neuritis.
  • DANTE T1-SPACE aids in understanding the relationship between imaging findings and clinical presentation.