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Related Concept Videos

  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. In-depth Study Of Pyroptosis-related Genes And Immune Infiltration In Colon Cancer.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. In-depth Study Of Pyroptosis-related Genes And Immune Infiltration In Colon Cancer.

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Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells
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In-depth study of pyroptosis-related genes and immune infiltration in colon cancer.

Bingbing Shang1,2, Haiyan Qiao1, Liang Wang1

  • 1Laboratory Animal Center, Dalian Medical University, Dalian, China.

Peerj
|November 4, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Pyroptosis-related genes (PRGs) are linked to colon cancer progression. This study identified 10 hub PRGs, including TNNC1, which may serve as diagnostic biomarkers for colon cancer treatment.

Keywords:
Colon cancerHeterogeneityImmune infiltrationPyroptosis-related genes

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Pyroptosis, a form of regulated necrosis, is implicated in tumor progression.
  • Pyroptosis-related genes (PRGs) have diagnostic potential in colon cancer.
  • Understanding PRG expression is crucial for colon cancer research.

Purpose of the Study:

  • To investigate the relationship between PRG expression and colon cancer.
  • To identify potential diagnostic and therapeutic targets for colon cancer.
  • To explore the role of PRGs in the tumor microenvironment.

Main Methods:

  • Utilized The Cancer Genome Atlas (TCGA) colon adenocarcinoma data.
  • Performed unsupervised clustering to identify pyroptosis subtypes.
  • Selected 10 hub PRGs through differential expression and network analysis.
TNNC1
  • Conducted Gene Ontology, KEGG, GSVA, PPI, and immune infiltration analyses.
  • Validated TNNC1 expression using immunohistochemistry and qPCR.

    • Main Results:

    • Identified 10 hub PRGs associated with colon cancer.
    • Found associations between PRGs and immune cell infiltration.
    • TNNC1 expression positively correlated with immature dendritic cells and NK CD56+ cells.
    • TNNC1 expression was elevated in colon tumor tissues and cell lines.

    Conclusions:

    • Characterized PRG expression patterns in colon cancer.
    • Identified novel biological targets for early diagnosis and individualized treatment.
    • Highlighted TNNC1 as a potential biomarker for colon cancer.