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Updated: Jun 8, 2025

Author Spotlight: Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing
Published on: March 17, 2023
A focus on capacitive cation sensing under flow: play it again SAM
Debapriya Gupta1, Amar H Flood1
1Department of Chemistry, Indiana University 800 East Kirkwood Avenue Bloomington IN 47405 USA aflood@iu.edu.
Abstract:
We highlight an article by Patrick et al. (S. C. Patrick, R. Hein, P. D. Beer and J. J. Davis, Chem. Sci., 2024, https://doi.org/10.1039/D4SC05271D) that integrates capacitance spectroscopy with a continuous flow assay to achieve reagentless electrochemical sensing. Injection of analytes leads to ion recruitment by the self-assembled monolayer (SAM) of benzo-15-crown-5 receptors generating spikes in the sensorgram. Injecting the supporting electrolyte regenerates the vacant receptor, returning the value to baseline. Binding and debinding kinetic signatures also emerge. The continuous and sensitive reporting of interfacial host-guest binding in real-time follows the precision of a well-composed melody that can be played again and again.
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