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Insertable Biomaterial-Based Multianalyte Barcode Sensor toward Continuous Monitoring of Glucose and Oxygen.

Ridhi Pradhan¹, David Chimene¹, Brian S Ko¹

¹Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, United States.

|November 4, 2024

Summary

A novel optical barcode sensor enables simultaneous, continuous monitoring of glucose and oxygen in tissues. This biocompatible device offers stable, reproducible measurements, paving the way for advanced chronic disease management.

Keywords:

barcode biocompatible continuous glucose monitoring hydrogel insertable multianalyte optical sensor oxygen monitoring

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Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level

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Published on: November 17, 2013

Area of Science:

Biomedical Engineering
Analytical Chemistry
Materials Science

Background:

Chronic diseases like diabetes and cardiovascular conditions are major global health burdens.
Current single-analyte monitoring tools limit comprehensive disease management.
Multiplexing technologies offer a promising avenue for simultaneous biomarker detection.

Purpose of the Study:

To develop and evaluate a miniaturized, biocompatible optical "barcode" sensor for continuous glucose and oxygen monitoring.
To assess the sensor's performance in low-oxygen tissue environments and its stability over time.
To demonstrate the sensor's capability for multiplexed analyte detection without crosstalk.

Main Methods:

Fabrication of a poly(ethylene glycol) diacrylate (PEGDA) hydrogel sensor with discrete compartments for glucose and oxygen-sensing phosphorescent microparticles.
Evaluation of sensor response to physiological glucose fluctuations under low oxygen conditions.
Assessment of storage stability, reproducibility, sterilization effects, and chronic tissue response in vivo.

Main Results:

The barcode sensor demonstrated tunable dynamic range and sensitivity for glucose monitoring in low oxygen.
The device exhibited excellent storage stability (>12 weeks), reversibility, and reproducibility (∼6% variability).
Electron beam sterilization had minimal impact; sensors showed multiplexed sensing without crosstalk and good biocompatibility in chronic animal studies.

Conclusions:

The developed optical barcode sensor is a promising technology for simultaneous, continuous monitoring of glucose and oxygen.
Its high biocompatibility, stability, and multiplexing capability support its potential for managing chronic conditions.
This technology advances optical assays for multiple biomarkers, enabling better patient feedback and disease management.