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Peripheral Endothelial Dysfunction Is Associated With Incident Major Depressive Disorder.

Jaskanwal D S Sara¹, Nazanin Rajai¹, Scott Breitinger²

¹Department of Cardiovascular Medicine Mayo College of Medicine Rochester MN.

Journal of the American Heart Association

|November 4, 2024

Summary

Peripheral endothelial dysfunction (PED) is linked to a higher risk of developing major depressive disorder (MDD). This vascular condition may help identify individuals who could benefit from early depression management strategies.

Keywords:

chest pain depression endothelial dysfunction ischemia

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Area of Science:

Cardiology
Psychiatry
Vascular Medicine

Background:

Major depressive disorder (MDD) is associated with cardiovascular risk factors and cerebral small-vessel disease.
Endothelial dysfunction is linked to MDD, but prospective data on peripheral endothelial dysfunction (PED) and incident MDD is lacking.

Purpose of the Study:

To investigate the prospective association between peripheral endothelial dysfunction (PED) and the incidence of major depressive disorder (MDD).

Main Methods:

Evaluated 1614 patients for PED using reactive hyperemia-peripheral arterial tonometry.
Reviewed medical records to identify 484 patients with subsequent MDD evaluations (0-15 years post-PED assessment).
Used logistic regression to analyze the association between baseline PED and incident MDD.

Main Results:

30.1% of patients had PED; 31.0% were diagnosed with MDD.
Individuals with MDD showed a higher frequency of PED (40.2% vs. 30.2%, P=0.034).
PED was significantly associated with incident MDD (OR, 2.3; 95% CI, 1.4-3.8; P<0.001).

Conclusions:

Peripheral endothelial dysfunction is significantly associated with incident major depressive disorder.
PED may serve as a valuable biomarker for identifying individuals at elevated risk for depression.
Early and frequent management strategies may benefit individuals identified with PED.