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Updated: Jun 8, 2025
Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
Published on: May 24, 2016
The Impact of Maternal Passive Tobacco Smoke on Neonatal Myocardiopathy in Mice
Naseer Kawish1, Muddasir Hassan Abbasi2, Muhammad Babar Khawar3
1Cell & Molecular Biology Lab, Institute of Zoology, University of the Punjab, Lahore, Pakistan.
Background:
Tobacco smoke has a global impact, particularly on pregnant women and their newborns. An emerging body of research suggests that passive tobacco smoking is a significant contributor to congenital cardiovascular disorders (CVDs).
Aim Of The Study:
This study aimed to mimic the effects of passive tobacco smoke (PTS) on neonates exposed throughout the gestational period.
Methods:
Female mice (DPC = 0) were exposed to PTS; 24 cigarettes/day with an interval of 10 min between each cigarette in a specialized smoke chamber from conception to birth. Histopathological analysis was employed to evaluate PTS-induced cardiac damage in neonates.
Results:
The results revealed significant alterations in cell structure, namely, widened interstitial spaces, hemorrhage, pyknotic nuclei, inflammatory cell infiltration, collagen deposition, and fibrosis.
Conclusion:
Maternal exposure to PTS during pregnancy may lead to neonatal myocardiopathy.
