Synergetic antibacterial nanosheet based on Ti3C2T photothermal therapy and cationic polymer to eradicate
Chuming Pang1, Yingxin Tan1, Jiahao Ling1
1School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China. mslzhong@scut.edu.cn.
Abstract:
Drug-resistant bacteria infection and biofilm formation on the wound still pose a tremendous challenge in post-antibiotic era. It has been proposed that multimode synergetic antibacterial strategies may be employed to eradicate drug-resistant bacteria and biofilms effectively. In this study, we synthesized non-invasive antibacterial two-dimension (2D) composite nanosheet BPG using Ti3C2T MXene and cationic borneol-guanidine based polymers (B-PGMA-Gu) via simple electrostatically co-assemble. BPG can target bacteria and efficiently eliminate Gram-positive bacteria Staphylococcus aureus (S. aureus), Gram-negative bacteria Escherichia coli (E. coli), and methicillin-resistant Staphylococcus aureus (MRSA) under 808 nm radiation. By combining the photothermal properties of Ti3C2T MXene and the excellent membrane penetration ability of B-PGMA-Gu, MRSA biofilms can be effectively removed at 100 μg mL-1 under laser irradiation, resulting in a bactericidal efficiency of 99.1%. This method offers a more effective and rapid non-antibiotic method for removing biofilms.
