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Diphacinone-induced coagulopathy in the dog
Journal of the American Veterinary Medical Association
|February 15, 1986
Summary
Rodenticide poisoning from indanedione-based products can cause severe coagulopathy. Prompt treatment with vitamin K1 is crucial for recovery in affected animals.
Area of Science:
- Veterinary Toxicology
- Internal Medicine
Background:
- Indanedione-based rodenticides, such as diphacinone, are commonly used but can cause toxicity.
- Coagulopathy is a known risk associated with anticoagulant rodenticide ingestion.
Observation:
- Acute onset of lethargy and respiratory distress were the primary clinical signs in five cases.
- Thoracic radiography consistently showed pulmonary edema, pleural effusion, and/or pericardial effusion.
Findings:
- Laboratory tests confirmed coagulopathies in all affected individuals.
- All cases demonstrated a positive response to vitamin K1 therapy, indicating its efficacy.
Implications:
- This report highlights the significant risk of cardiovascular and pulmonary complications from indanedione rodenticide exposure.
- Early recognition of clinical signs and prompt administration of vitamin K1 are vital for successful management of rodenticide-induced coagulopathy.