A Territory-Wide Follow-Up of Primary and Secondary Extramammary Paget Disease of 2 Decades: Effects of Local Disease on Survival
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View abstract on PubMed
Summary
This summary is machine-generated.Secondary Extramammary Paget disease (EMPD) is linked to worse outcomes. Margin involvement is a key predictor of shorter survival, emphasizing the importance of clear surgical margins for better prognosis in EMPD patients.
Area Of Science
- Oncology
- Dermatology
- Pathology
Background
- Extramammary Paget disease (EMPD) is a rare malignant skin neoplasm with primary and secondary forms.
- This study investigates clinical outcomes of primary and secondary EMPD.
Purpose Of The Study
- To analyze clinical outcomes and prognostic factors in patients with primary and secondary Extramammary Paget disease.
- To conduct a subgroup analysis for secondary EMPD outcomes.
Main Methods
- Retrospective review of 109 histologically confirmed EMPD cases over two decades.
- Clinicopathological and outcome data were collected for statistical analysis.
Main Results
- Secondary EMPD, often associated with colorectal, anal, or prostatic carcinomas, showed poorer outcomes.
- Older age, male sex, and margin involvement were associated with shorter overall survival (OS) and disease-specific survival (DSS).
- Margin involvement independently predicted shorter OS and DSS, particularly in secondary EMPD.
Conclusions
- Secondary EMPD is associated with significantly poorer prognoses compared to primary EMPD.
- Surgical margin status is a critical independent predictor of survival in EMPD.
- Achieving clear surgical margins is crucial for improving patient outcomes in EMPD.
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