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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Related Experiment Video

Updated: Jun 8, 2025

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
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Human iPSC-Derived MSCs Induce Neurotrophic Effects and Improve Metabolic Activity in Acute Neuronal Injury Models.

Keiji Kawatani1, Genesis Omana Suarez1,2, Ralph B Perkerson3

  • 1Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 4, 2024
PubMed
Summary

Induced pluripotent stem cell-derived mesenchymal stromal cells (iMSCs) show therapeutic potential for neurological disorders. Their secretome enhances neuronal survival, outgrowth, and metabolic activity, aiding brain injury recovery.

Keywords:
MSCiPSCneuronneurotrophic effectstem cell therapy

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High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
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Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Stem Cell Biology

Background:

  • Mesenchymal stromal cell (MSC) therapy shows promise for neurological diseases, but clinical outcomes vary due to MSC heterogeneity.
  • Induced pluripotent stem cells (iPSCs) offer a consistent source for MSC expansion and biomanufacturing.
  • iPSC-derived MSCs (iMSCs) present a potential solution to overcome limitations of traditional MSC therapy.

Purpose of the Study:

  • To investigate the therapeutic effects of iPSC-derived MSCs (iMSCs) on iPSC-derived neurons.
  • To evaluate the neurotrophic, metabolic, and in vivo effects of iMSC secretome and iMSCs in neurological damage models.

Main Methods:

  • In vitro analysis of iMSC secretome effects on neuronal survival, outgrowth, and synaptic activity.
  • Assessment of neuronal metabolic activity (mitochondrial respiration and glycolysis) following iMSC administration.
  • In vivo studies using mouse models of irradiation-induced brain injury, including intravenous iMSC administration and 18F-FDG PET imaging.

Main Results:

  • iMSC secretome demonstrated neurotrophic effects, improving neuronal survival, outgrowth, and synaptic activity in vitro.
  • iMSCs enhanced neuronal metabolic activity via mitochondrial respiration and glycolysis, both in vitro and in vivo.
  • Intravenous iMSC administration in mice with brain injury restored synaptic metabolic activity and increased brain glucose uptake.

Conclusions:

  • iMSC-derived secretome exhibits significant neurotrophic and metabolic benefits for neurons.
  • iMSC therapy effectively addresses energetic deficits in brain injury models, restoring metabolic activity.
  • iMSCs hold considerable potential for regenerative medicine applications in treating neurological disorders.