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Bicarbonate buffering of lactic acid generated during exercise.

W L Beaver, K Wasserman, B J Whipp

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |February 1, 1986
    PubMed
    Summary

    During exercise, the body

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    Commentaries.

    Canadian Medical Association journal·2010

    Area of Science:

    • Exercise Physiology
    • Biochemistry

    Background:

    • Lactic acid accumulation during exercise is buffered by the bicarbonate system.
    • Understanding the buffering dynamics is crucial for exercise performance research.

    Purpose of the Study:

    • To quantify the buffering of lactic acid by bicarbonate during progressive incremental exercise.
    • To investigate the timing and extent of bicarbonate buffering in response to lactate increase.

    Main Methods:

    • Analysis of arterial bicarbonate ([HCO3-]) and lactate ([La-]) concentrations during incremental exercise in 10 subjects.
    • Development of a mathematical model based on log-log transformation to analyze changes beyond the lactate threshold.
    • Comparison of regression models to assess the relationship between [HCO3-] decrease and [La-] increase.

    Main Results:

    • The decrease in [HCO3-] closely matched the increase in [La-].
    • Optimal model fit occurred when the [HCO3-] decrease was delayed until [La-] increased by ~0.4 meq/l.
    • This suggests initial intracellular buffering of lactic acid before bicarbonate system involvement.

    Conclusions:

    • The bicarbonate buffer system is the primary buffer for lactic acid during intense exercise.
    • Intracellular buffering mechanisms precede and complement extracellular bicarbonate buffering.
    • This provides insights into acid-base regulation during exercise and metabolic acidosis.

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