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Related Experiment Video

Updated: Jun 8, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

Microbiota and cognitive impairment: Current challenges and future perspectives.

Guillaume Chapelet^1,2,3, Wendy Noble², Pascal Derkinderen¹

¹Nantes University, Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France.

Journal of Alzheimer'S Disease : JAD

|November 5, 2024

Summary

Gut microbiota may impact cognitive function. Lower beneficial bacteria and diversity are linked to cognitive impairment, suggesting gut bacteria as a potential biomarker for cognitive vulnerability.

Keywords:

Alzheimer's disease aging biomarker dementia frailty microbiota neurocognitive disease nutrition older patient short chain fatty acid

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

Neuroscience
Microbiology
Gastroenterology

Background:

Emerging research suggests a connection between the gut microbiome and brain health.
Cognitive impairment is often associated with reduced gut microbial diversity and a decrease in beneficial bacteria.

Purpose of the Study:

To explore the role of gut microbiota as a potential biomarker for cognitive vulnerability.
To highlight the need for further investigation into the mechanisms linking microbiota, lifestyle, and cognitive health.

Main Methods:

Review of recent studies on gut microbiota and cognitive function.
Analysis of correlations between microbial composition and cognitive impairment.

Main Results:

Individuals with cognitive impairment exhibit altered gut microbiota profiles, characterized by fewer beneficial bacteria and lower diversity.
Gut microbiota composition may serve as an indicator of susceptibility to cognitive decline.

Conclusions:

Gut microbiota represents a promising area for understanding and potentially intervening in cognitive health.
Further research is warranted to elucidate the causal relationships and identify effective strategies for prevention and treatment.