Prognostic prediction and treatment options for gastric signet ring cell carcinoma: a SEER database analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Gastric signet ring cell carcinoma (SRCC) has a poorer prognosis than adenocarcinoma. This study identified key prognostic factors and developed a nomogram to guide personalized treatment strategies for SRCC patients, differentiating between high-risk and low-risk groups.
Area Of Science
- Oncology
- Gastroenterology
- Cancer Research
Background
- Gastric signet ring cell carcinoma (SRCC) incidence is rising despite a general decrease in gastric cancer rates.
- SRCC exhibits more aggressive behavior compared to non-SRCC subtypes like adenocarcinoma.
- Understanding SRCC prognostic factors is crucial for improving diagnosis and patient outcomes.
Purpose Of The Study
- To investigate prognostic factors influencing survival in gastric signet ring cell carcinoma (SRCC) patients.
- To develop and validate prognostic nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) in SRCC.
- To stratify SRCC patients into risk groups for personalized treatment recommendations.
Main Methods
- Utilized SEER database (1992-2020) and external validation data from Soochow University.
- Constructed prognostic nomograms to predict 1 and 2-year OS and CSS for SRCC patients.
- Employed propensity score matching (PSM), multivariate Cox regression, AIC, DCA, calibration curves, C-index, and AUC for model validation.
Main Results
- Multivariate analysis identified T stage, N stage, M stage, and surgical approach as independent prognostic factors for SRCC.
- Validated prognostic nomograms accurately predicted OS and CSS for SRCC patients.
- Stratified patients into high-risk and low-risk groups; low-risk patients benefited from surgery alone, while high-risk patients were better treated with surgery plus chemotherapy.
Conclusions
- Gastric signet ring cell carcinoma (SRCC) has a less favorable prognosis compared to adenocarcinoma, particularly concerning cancer-specific survival.
- Developed and validated nomograms provide a reliable tool for predicting OS and CSS in SRCC patients.
- The study facilitates individualized treatment strategies by stratifying SRCC patients into distinct risk categories.
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