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Updated: Jun 8, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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YB1 and its role in osteosarcoma: a review

Feipeng Wu1, Dapeng Li1

  • 1Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.

Frontiers in Oncology
|November 5, 2024
PubMed

Insights

Y box binding protein 1 (YB1) is crucial for cell processes and cancer. This review highlights YB1's role in osteosarcoma, offering insights for new cancer therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Y box binding protein 1 (YB1) is a multifunctional DNA/RNA-binding protein involved in fundamental cellular processes.
  • YB1 regulates transcription, translation, DNA repair, proliferation, differentiation, and apoptosis.
  • Aberrant YB1 expression is implicated in various cancers, including osteosarcoma.

Purpose of the Study:

  • To review the diverse functions of YB1.
  • To elucidate the critical role of YB1 in osteosarcoma progression.
  • To explore potential therapeutic strategies targeting YB1 in osteosarcoma.

Main Methods:

  • Literature review of YB1 functions and its involvement in cancer.
  • Analysis of studies focusing on YB1's role in osteosarcoma development and progression.
  • Synthesis of current knowledge on YB1-targeting therapeutic approaches.

Main Results:

  • YB1 participates in multiple cellular mechanisms vital for cell survival and function.
  • Evidence demonstrates YB1's significant contribution to osteosarcoma initiation and advancement.
  • Dysregulation of YB1 is a common feature in osteosarcoma.

Conclusions:

  • YB1 is a key player in cellular regulation and oncogenesis.
  • Targeting YB1 presents a promising avenue for novel osteosarcoma treatments.
  • Further research into YB1's mechanisms may unlock innovative therapeutic strategies.
Keywords:
YB1YBX1 phosphorylationosteosarcomasplicing factortreatment of osteosarcoma

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