Coagulation-related genes for thyroid cancer prognosis, immune infltration, staging, and drug sensitivity
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View abstract on PubMed
Summary
This summary is machine-generated.Coagulation biomarker D-dimer predicts lateral lymph node metastasis in thyroid cancer (THCA). A prognostic model based on 8 coagulation-related genes improves risk stratification for personalized THCA therapy.
Area Of Science
- Endocrinology
- Oncology
- Molecular Biology
- Biomarker Discovery
Background
- Thyroid cancer (THCA) is the most common endocrine malignancy.
- The role of coagulation in THCA development and progression remains unclear.
- Identifying predictive biomarkers for THCA metastasis is crucial for patient management.
Purpose Of The Study
- To evaluate the predictive value of D-dimer for lateral lymph node metastasis (LLNM) in THCA patients.
- To identify coagulation-related genes (CRGs) associated with THCA prognosis.
- To construct and validate a prognostic model for THCA based on CRGs.
Main Methods
- Receiver operating characteristic (ROC) and logistic regression analyses were used to assess D-dimer's predictive value for LLNM.
- Consensus clustering analysis of TCGA database identified coagulation-related molecular subtypes.
- LASSO regression selected 8 CRGs to build a prognostic model, followed by risk stratification, nomogram construction, and RT-qPCR validation.
Main Results
- D-dimer demonstrated predictive value for LLNM (AUC=0.656), with elevated levels (>0.065 mg/l) being an independent predictor.
- A prognostic model using 8 CRGs effectively distinguished between high-risk and low-risk THCA patients (P<0.001).
- Significant differences in clinical characteristics, gene mutations, immune infiltration, and drug sensitivity were observed between risk groups; 8 CRGs were overexpressed in THCA cell lines.
Conclusions
- Coagulation biomarkers, particularly D-dimer, hold significant potential for predicting LLNM in THCA.
- The developed prognostic model based on CRGs offers a novel tool for risk stratification and personalized therapy in THCA.
- This study provides a foundation for understanding coagulation's role in THCA and guides future research in targeted treatments.
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