Recurrent Post-viral Rhabdomyolysis: A Case Report
Alyssa Breedlove1, Ashton Rohrschneider2, Richard Virgilio3
1Clinical, Biomedical, and Educational Research, Edward Via College of Osteopathic Medicine, Spartanburg, USA.
Cureus
|November 5, 2024
Summary
Rhabdomyolysis, a condition from muscle damage, can be life-threatening. This case highlights recurrent rhabdomyolysis after viral illness, suggesting a potential genetic link in some individuals.
Area of Science:
- Medicine
- Genetics
- Pathology
Background:
- Rhabdomyolysis involves muscle cell breakdown and content release.
- It is often triggered by extreme physical exertion.
- Severe complications include acute kidney injury and mortality.
Observation:
- A middle-aged male experienced five episodes of rhabdomyolysis over nine years.
- Each episode followed a viral infection.
- Standard tests ruled out metabolic, neuromuscular, and myopathic causes.
Findings:
- Two variants of unknown significance were identified in the SYNE2 gene.
- The SYNE2 gene is associated with Emery-Dreifuss muscular dystrophy.
- No definitive cause for recurrent rhabdomyolysis was established.
Implications:
- Recurrent rhabdomyolysis may have an underlying genetic predisposition.
- Viral infections could be triggers in susceptible individuals.
- Further research is needed to understand the role of SYNE2 variants in rhabdomyolysis.
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