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Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
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Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
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In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the fermentor via a sparger...
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A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
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Biofuser: a multi-source data fusion platform for fusing the data of fermentation process devices.

Dequan Zhang1, Wei Jiang2, Jincheng Lou2

  • 1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.

Frontiers in Digital Health
|November 5, 2024
PubMed
Summary

A new platform, Biofuser, integrates diverse bioprocess data for enhanced optimization. This facilitates machine learning applications, accelerating intelligent biomanufacturing and synthetic biology industrialization.

Keywords:
Biofuserbioprocess optimizationintelligent biomanufacturingmulti-source data fusionmulti-source heterogeneous data

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Area of Science:

  • Biotechnology
  • Synthetic Biology
  • Process Engineering

Background:

  • Traditional bioprocess optimization lags behind synthetic biology advancements.
  • Increased use of advanced sensors generates heterogeneous data, complicating analysis.
  • Need for integrated data solutions to bridge the gap between research and industrial application.

Purpose of the Study:

  • To introduce Biofuser, a novel multi-source data fusion platform.
  • To enable seamless integration and processing of heterogeneous bioprocess data.
  • To support advanced analytics, modeling, and control for bioprocess optimization.

Main Methods:

  • Development of a platform for collecting and processing multi-source heterogeneous data.
  • Data integration into a unified format for visualization, analysis, and model construction.
  • Provision of APIs for machine learning and deep learning integration.

Main Results:

  • Demonstrated successful application in a riboflavin fermentation process.
  • Enabled identification of device faults and critical process factors.
  • Showcased capability in accurate bioprocess prediction.

Conclusions:

  • Biofuser significantly enhances fermentation optimization techniques.
  • The platform is crucial infrastructure for integrating artificial intelligence into bioprocesses.
  • Expected to accelerate the development of intelligent biomanufacturing.