Related Experiment Video
Updated: Jun 8, 2025
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
MicroRNAs in Aseptic Loosening of Prosthesis: Pathophysiology and Potential Therapeutic Approaches
Reza Minaei Noshahr1, Farzad Amouzadeh Omrani2, Atefeh Yadollahzadeh Chari3
1Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objectives:
Aseptic loosening (AL) is one of the leading causes of total joint arthroplasty (TJA) revision. Discovering the roles of microRNAs (miRNA/miR) in ontogenesis and osteolysis has attracted more attention to diagnosing and treating bone disorders. This review aimed to summarize miRNA biogenesis and describe the involvement of miRNAs in AL of implants.
Methods:
A detailed search was carried out on scientific search engines, including Google Scholar, Web of Science, and PubMed, to find appropriate papers related to subjects. The search process was performed using the following keywords: "Implant", "miRNAs", "Wear particles", "Osteoclasts", "Total joint replacement", and "Osteolytic diseases".
Results:
miRNAs play an essential role in the regulation of gene expression. AL is associated with several pathologic properties, including wear particle-induced persistent inflammatory response, unbalanced osteoclastogenesis, abnormal osteoblast differentiation, and maturation. Recent researches have revealed that these pathological events are closely associated with miRNA deregulation, confirming the relationship between miRNA and AL of prostheses.
Conclusion:
With the results of the new approaches to target miRNA, the essential role of miRNA is further defined. Understanding the mechanisms of miRNAs and related signaling pathways in the pathophysiology of AL will help scientists illuminate novel therapeutic strategies and specific targeted drugs.
Insights
MicroRNAs (miRNAs) are crucial in regulating gene expression and are implicated in aseptic loosening (AL) of implants. Understanding miRNA
Area of Science:
- Biomedical Engineering
- Molecular Biology
- Orthopedics
Background:
- Aseptic loosening (AL) is a primary cause for total joint arthroplasty (TJA) revision.
- MicroRNAs (miRNAs) are increasingly recognized for their roles in bone development and osteolysis.
- Investigating miRNAs offers potential for diagnosing and treating bone disorders.
Purpose of the Study:
- To review miRNA biogenesis.
- To elucidate the involvement of miRNAs in the aseptic loosening of implants.
Main Methods:
- Comprehensive literature search on Google Scholar, Web of Science, and PubMed.
- Keywords included: Implant, miRNAs, Wear particles, Osteoclasts, Total joint replacement, Osteolytic diseases.
Main Results:
- miRNAs regulate gene expression and are implicated in AL.
- Pathological features of AL, such as inflammation and imbalanced osteoclastogenesis, are linked to miRNA deregulation.
- miRNA dysregulation is confirmed to be associated with implant AL.
Conclusions:
- Targeting miRNAs offers new therapeutic strategies for AL.
- Understanding miRNA mechanisms in AL pathophysiology can lead to novel drugs and treatments.
