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Related Experiment Video

Updated: Jun 8, 2025

Animal Models of Depression - Chronic Despair Model CDM
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Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function.

Liqin Huang1, Shangqi Sun2, Gege Jiang1

  • 1Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.

Frontiers in Molecular Neuroscience
|November 5, 2024
PubMed
Summary
This summary is machine-generated.

Follicle-stimulating hormone (FSH) induces depression-like behaviors in mice by increasing inflammation and impairing synaptic plasticity. Targeting the FSH receptor may offer a new therapeutic strategy for depression.

Keywords:
FSHGABAdepressionglutamateinflammationsynaptic plasticity

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychiatry

Background:

  • Depression is a common mood disorder, particularly in women experiencing hormonal fluctuations.
  • Estrogen's neuroprotective effects on depression are known, but the role of follicle-stimulating hormone (FSH) remains unclear.
  • Hormonal changes during puberty, peripartum, and menopause increase women's susceptibility to depression.

Purpose of the Study:

  • To investigate the role of FSH in depression.
  • To explore the underlying mechanisms of FSH-induced depression-like behaviors.
  • To assess the potential of targeting the FSH receptor (FSHR) for depression treatment.

Main Methods:

  • Administered varying doses of FSH to mice to observe depression-like behaviors.
  • Measured levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) in serum and hippocampus.
  • Assessed synaptic plasticity and expression of synaptic proteins.
  • Knocked down FSH receptor (FSHR) expression in the hippocampus to evaluate its effect.

Main Results:

  • FSH induced depression-like behaviors in a dose-dependent manner.
  • FSH elevated pro-inflammatory cytokines and impaired synaptic plasticity.
  • Reduced expression of key synaptic proteins was observed after FSH treatment.
  • Knocking down FSHR in the hippocampus alleviated FSH-induced depression-like behaviors and associated pathologies.

Conclusions:

  • FSH plays a significant role in the pathogenesis of depression.
  • FSH-induced depression is linked to inflammation and impaired synaptic plasticity.
  • Targeting FSH or its receptor presents a potential therapeutic avenue for depression associated with hormonal fluctuations in women.