Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

2.4K
2.4K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Next-generation Sequencing03:00

Next-generation Sequencing

87.6K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
87.6K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K
Genomics02:02

Genomics

36.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.0K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

46.7K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
46.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disentangling production and persistence of extracellular virions in grassland soils with SIP-viromics.

mSystems·2026
Same author

Microbiome Science Certificate Program for workforce development and multi-omics expertise.

Journal of microbiology & biology education·2026
Same author

Draft genome sequence of <i>Aquicella lusitana</i> DSM 16500<sup>T</sup> isolated from a spa.

Microbiology resource announcements·2026
Same author

Genome sequences of seven <i>Streptomyces</i> isolates for genome prospecting.

Microbiology resource announcements·2026
Same author

Author Correction: Human cerebrospinal fluid net flow enhanced by respiration during the awake state.

Nature communications·2026
Same author

Multi-omics reveals nitrogen dynamics associated with soil microbial blooms during snowmelt.

Nature microbiology·2026

Related Experiment Video

Updated: Jun 8, 2025

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

9.1K

Genomes OnLine Database (GOLD) v.10: new features and updates.

Supratim Mukherjee1, Dimitri Stamatis1, Cindy Tianqing Li1

  • 1DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Nucleic Acids Research
|November 5, 2024
PubMed
Summary

The Genomes OnLine Database (GOLD) is a vital resource for genomic metadata, now enhanced with new features for easier data access and analysis. It supports global research collaboration and integrates diverse datasets for improved scientific insights.

More Related Videos

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
10:40

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

10.4K
Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
04:58

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

2.2K

Related Experiment Videos

Last Updated: Jun 8, 2025

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

9.1K
Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
10:40

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

10.4K
Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
04:58

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

2.2K

Area of Science:

  • Genomics
  • Bioinformatics
  • Data Management

Background:

  • The Genomes OnLine Database (GOLD) has served as a key metadata repository for (meta)genomic projects since 1997.
  • It facilitates access to comprehensive metadata across Study, Organism/Biosample, Sequencing Project, and Analysis Project levels.

Purpose of the Study:

  • To provide an update on the Genomes OnLine Database (GOLD).
  • To highlight new features and expansions implemented over the last two years.
  • To emphasize GOLD's role as a collaborative platform for genomic metadata.

Main Methods:

  • Data integration from primary repositories like NCBI.
  • Incorporation of worldwide researcher contributions.
  • Expansion of metadata fields, features, search capabilities, and visualization tools.

Main Results:

  • Significant growth and enrichment of the GOLD database.
  • Enhanced usability through intuitive features and advanced search.
  • Improved data visualization for better interpretation of genomic information.

Conclusions:

  • GOLD continues to be an indispensable resource for the scientific community.
  • Recent updates enhance its collaborative capabilities and data accessibility.
  • The expanded features cater to the growing demand for integrated genomic metadata.