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Poststreptococcal acute glomerulonephritis with 22F pneumococcal bacteremia
Hinako Itagaki1, Yoshitaka Watanabe1, Naomi Yagi1
1Children's Medical Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki Chuo, Tsuzuki-Ku, Yokohama, 225-8503, Japan.
Background:
Pneumococcal vaccines have been available worldwide since the early 2000s; consequently, few reports exist of poststreptococcal acute glomerulonephritis (PSAGN) or complications of pneumococcal infection. We describe a patient with PSAGN and bacteremia with Streptococcus pneumoniae serotype 22F (not covered by the 13-valent pneumococcal vaccine (PCV 13)).
Case Diagnosis/Treatment:
A 5-year-old boy received the PCV13 vaccine and was admitted to our hospital with a fever and gross hematuria. A throat swab was positive for a streptococcal antigen, and his serum anti-streptolysin O and creatinine levels were increased. Low serum C3 levels suggested PSAGN, with an infiltrating shadow on chest X-ray. His blood culture isolated S. pneumoniae serotype 22F, and he was administered intravenous ceftriaxone for 10 days. His kidney function, pneumonia, and bacteremia improved.
Conclusions:
Children with PSAGN should be evaluated for pneumococcal bacteremia due to strains not covered by the vaccine.
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