Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fungal Group Zygomycota

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prime editing for precise genome engineering and modulation of fungal metabolism.

Nature biotechnology·2026

Same author

Data-Driven Adaptive Tracking Control for Nonlinear New Quality Productive Forces Systems with Input Constraints.

Entropy (Basel, Switzerland)·2026

Same author

Stress granules promote DNA damage repair through the G3BP1/NAT10/ATF3 axis to facilitate nasopharyngeal carcinoma progression.

Oncogene·2026

Same author

Advances in multiplex precision genome editing in eukaryotic and prokaryotic systems.

Current opinion in biotechnology·2026

Same author

Comparison of Surgical Outcomes of Ab Interno Trabeculotomy Using Tanito Microhook, Suture, and Trabectome.

Journal of glaucoma·2026

Same author

Mechanism of tobacco-sweet potato intercropping in suppressing <i>Ralstonia solanacearum</i> in flue-cured tobacco.

Frontiers in plant science·2025

Search research articles

Related Experiment Video

Updated: Jun 8, 2025

Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level

Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level

Published on: June 23, 2022

Exploring Bioactive Fungal RiPPs: Advances, Challenges, and Future Prospects.

Qiuyue Nie^1,2, Chunxiao Sun^1,2, Shuai Liu^1,2

¹Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

|November 5, 2024

Summary

Fungal ribosomally synthesized and post-translationally modified peptides (RiPPs) are potent natural products. This review explores their biosynthesis and genome-guided discovery, highlighting potential for new therapeutics.

Keywords:

bioactivity bioinformatics biosynthesis fungal RiPPs precursor peptides

More Related Videos

Live-cell Imaging of Fungal Cells to Investigate Modes of Entry and Subcellular Localization of Antifungal Plant Defensins

Live-cell Imaging of Fungal Cells to Investigate Modes of Entry and Subcellular Localization of Antifungal Plant Defensins

Published on: December 24, 2017

Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers

Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers

Published on: September 29, 2023

Related Experiment Videos

Last Updated: Jun 8, 2025

Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level

Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level

Published on: June 23, 2022

Live-cell Imaging of Fungal Cells to Investigate Modes of Entry and Subcellular Localization of Antifungal Plant Defensins

Live-cell Imaging of Fungal Cells to Investigate Modes of Entry and Subcellular Localization of Antifungal Plant Defensins

Published on: December 24, 2017

Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers

Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers

Published on: September 29, 2023

Area of Science:

Natural Product Chemistry
Mycology
Bioinformatics

Background:

Fungal ribosomally synthesized and post-translationally modified peptides (RiPPs) are a crucial class of natural products with diverse biological activities, including anticancer and immunosuppressant properties.
These compounds play significant roles in fungal chemical ecology and possess considerable therapeutic potential.
Despite their importance, the discovery of fungal RiPPs has been historically limited, with only a few known classes identified.

Purpose of the Study:

To review recent advancements in understanding fungal RiPP biosynthesis.
To highlight genome-guided strategies for discovering novel fungal RiPPs.
To propose integrated approaches for accelerating the identification of new bioactive fungal RiPPs.

Main Methods:

Review of current literature on fungal RiPP biosynthesis.
Analysis of bioinformatics tools and genome-mining strategies for RiPP discovery.
Discussion of gene-editing technologies in conjunction with biosynthetic knowledge.

Main Results:

Recent bioinformatics advancements reveal vast untapped potential for fungal RiPP production.
Established knowledge of fungal RiPP biosynthetic pathways is crucial for discovery.
Integration of bioinformatics, gene editing, and biosynthetic pathway knowledge is key.

Conclusions:

Combining knowledge of fungal RiPP biosynthetic pathways with advanced gene-editing technologies and bioinformatic tools will significantly accelerate the discovery of novel bioactive fungal RiPPs.
This integrated approach promises to unlock the therapeutic potential of these complex natural products.
Further research in this area is essential for expanding the repertoire of known fungal RiPPs and their applications.