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Oxygen supplementation and cognitive function in long-COVID.

Christine Gagnon1, Thomas Vincent1, Louis Bherer1

  • 1Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.

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|November 5, 2024
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Summary
This summary is machine-generated.

Supplemental oxygen therapy showed potential benefits for long-COVID cognitive deficits, improving global cognition, attention, and executive function. Further research is needed to confirm these findings in larger patient groups.

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Area of Science:

  • Neurology
  • Pulmonology
  • Rehabilitation Medicine

Background:

  • Long-COVID is associated with persistent cognitive impairments.
  • Inflammation and capillary damage may impair tissue oxygenation, contributing to cognitive deficits.

Purpose of the Study:

  • To explore the effects of supplemental oxygen therapy using a portable oxygen concentrator (POC) on cognitive function in long-COVID patients.
  • To assess changes in peripheral and cerebral oxygen saturation at rest and during exercise.

Main Methods:

  • An exploratory pilot crossover study involved 21 long-COVID participants.
  • Participants were randomized to receive either POC or standard care (Control) for two weeks, followed by a crossover.
  • Cognitive assessments (MoCA, Digit Span, etc.) and oxygen saturation measurements were taken at baseline and after each treatment period.

Main Results:

  • POC therapy showed a trend towards improved global cognition (MoCA scores) and specific cognitive domains like attention and visuospatial/executive function.
  • Improvements were also noted in working memory (Digit Span backward) and self-reported depressive symptoms.
  • No significant differences in cerebral or peripheral oxygen saturation were observed between POC and Control groups during exercise.

Conclusions:

  • Supplemental oxygen therapy may offer benefits for cognitive deficits and mood symptoms in long-COVID.
  • Larger studies are required to validate these preliminary findings and establish the efficacy of POC for long-COVID recovery.