Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

What is Genetic Engineering?

What is Genetic Engineering?

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Beginner's Guide to Decentralized Biobanking.

Biopreservation and biobanking·2026

Same author

Normalising transparency: an argument for requiring generative AI use declarations in all manuscripts-with a call for commentaries.

Journal of medical ethics·2026

Same author

Unique Digital Images as Incentives in Clinical Trials: A Digital Shift Toward Meaningful Participation.

Journal of medical Internet research·2026

Same author

Climate justice as a public health imperative: a perspective from Sierra Leone considering the 2025 International Court of Justice opinion.

Infectious diseases of poverty·2026

Same author

Ethics of AI in medicine: how smarter systems lead to tougher judgments.

Journal of medical ethics·2026

Same author

Generative AI can and should accelerate research evaluation reform to better recognize 'distinctly human contributions'.

Research Evaluation·2026

Same journal

Defending the Ethical Permissibility of Laryngeal Transplantation.

The American journal of bioethics : AJOB·2026

Same journal

A Framework of Institutional Obligations for Pragmatic Clinical Trials.

The American journal of bioethics : AJOB·2026

Same journal

Should Adherence to Medical Recommendations Be a Requirement for Kidney Transplant Candidacy?

The American journal of bioethics : AJOB·2026

Same journal

How "America First" Abandoned Global Health: The Case for an African Model.

The American journal of bioethics : AJOB·2026

Same journal

Carrots and Sticks: Incentives in Shaping Digital Health Products.

The American journal of bioethics : AJOB·2026

Same journal

From Empowerment to Offloading: Task Shifting and the Redistribution of Responsibility in Digital Health.

The American journal of bioethics : AJOB·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 8, 2025

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Enabling Demonstrated Consent for Biobanking with Blockchain and Generative AI.

Caspar Barnes^1,2, Mateo Riobo Aboy^3,4, Timo Minssen⁵

¹Harvard Medical School.

The American Journal of Bioethics : AJOB

|November 5, 2024

Summary

This summary is machine-generated.

This study introduces demonstrated consent, using blockchain and AI to track sample use for research. This ensures donors are informed about how their biological materials are utilized, enhancing transparency in research participation.

Keywords:

Informed consent biomedical research blockchain generative AI large language models (LLMs)research ethics

More Related Videos

Creation and Maintenance of a Living Biobank - How We Do It

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer

Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer

Published on: February 23, 2024

Related Experiment Videos

Last Updated: Jun 8, 2025

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Creation and Maintenance of a Living Biobank - How We Do It

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer

Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer

Published on: February 23, 2024

Area of Science:

Biomedical Ethics
Blockchain Technology
Artificial Intelligence

Background:

Ensuring informed consent for biological sample donation in research is challenging.
Current consent models struggle to adequately inform donors about future sample uses.
Lack of transparency can undermine voluntary participation in research.

Purpose of the Study:

To propose a novel consent framework called "demonstrated consent" for biological sample donation.
To leverage blockchain and generative AI to improve transparency and donor information.
To address the limitations of traditional consent models in research.

Main Methods:

Utilizing blockchain technology to create unique non-fungible tokens (NFTs) for each donated sample.
Storing metadata on NFTs detailing planned and past research uses of the biological samples.
Employing a customized large language model (LLM) to present complex usage data interactively and understandably.

Main Results:

A novel framework, "demonstrated consent," was developed using blockchain and generative AI.
Each sample is linked to an NFT that immutably records its research history.
LLM provides accessible explanations of sample usage, enhancing donor comprehension.

Conclusions:

Demonstrated consent offers a transparent and verifiable method for tracking biological sample usage.
Blockchain and AI integration can significantly improve informed consent in research.
This model empowers donors with clear information about their contributions to scientific research.