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Gender variations in 30-day outcomes following cholecystectomy in patients with biliary acute pancreatitis
Nicholas Stevens1, Ghazi-Abdullah Saroya1, Alain Elian1
1Department of Surgery, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA.
Insights
Male gender is linked to higher morbidity after cholecystectomy for biliary acute pancreatitis (BAP). However, gender does not impact 30-day mortality rates in these patients.
Area of Science:
- Gastroenterology
- Surgical Outcomes
- Health Disparities
Background:
- Biliary acute pancreatitis (BAP) presents significant morbidity and mortality risks.
- Cholecystectomy is a common intervention for BAP.
- The influence of patient gender on postoperative outcomes requires further investigation.
Purpose of the Study:
- To determine if male gender is associated with adverse 30-day postoperative outcomes after cholecystectomy for BAP.
- To compare morbidity and mortality rates between male and female patients undergoing cholecystectomy for BAP.
Main Methods:
- Analysis of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database from 2014-2017.
- Stratification of patients with BAP undergoing cholecystectomy into male and female groups.
- Comparison of demographic, perioperative, and 30-day outcomes using univariate and multivariable analyses.
Main Results:
- A total of 4158 patients (1556 male, 2602 female) were analyzed.
- Male patients exhibited significantly higher rates of serious and overall morbidity.
- Male gender independently predicted serious morbidity, but no significant difference in mortality was observed between genders.
Conclusions:
- Male gender is a significant risk factor for increased postoperative morbidity in patients with BAP undergoing cholecystectomy.
- While morbidity is higher in males, 30-day mortality rates are comparable between genders.
- These findings highlight potential gender-based disparities in surgical outcomes for BAP.
Background:
Biliary acute pancreatitis (BAP) can be associated with severe morbidity and mortality. This study aims to evaluate whether gender is associated with worse 30-day postoperative outcomes following cholecystectomy for BAP.
Methods:
Patients in the ACS-NSQIP database (2014-2017) with a diagnosis of BAP who underwent cholecystectomy were stratified into two groups: male and female. Patients' demographic characteristics, perioperative data, and 30- day outcomes between the two groups were compared using univariate and multivariable analyses.
Result:
4158 (1556 male, 2602 female) patients were examined. Male gender was found to have significantly higher rates of both serious and overall morbidity. On multivariable analysis, male gender was an independent predictor of serious morbidity. No difference in mortality between the two groups was noted.
Conclusion:
Male gender is associated with an increased rate of morbidity after cholecystectomy in patients with BAP, however there is no difference in mortality between the male and female genders.
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Assessment:
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include: