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Related Concept Videos

Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Pain01:20

Pain

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Related Experiment Video

Updated: Jun 8, 2025

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

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Stem cells feel the pain.

Jingyu Peng1, Mark J Khoury1, Ya-Chieh Hsu1

  • 1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

Developmental Cell
|November 5, 2024
PubMed
Summary

Pain signals injury and inflammation. New research reveals that pain also activates hair follicle stem cells (HFSCs) by regulating their niche, highlighting a novel role for pain beyond sensation.

Area of Science:

  • Stem cell biology
  • Dermatology
  • Neuroscience

Background:

  • Pain is a critical sensory signal indicating tissue damage or inflammation.
  • Hair follicle stem cells (HFSCs) are crucial for hair regeneration.
  • The microenvironment, or niche, regulates stem cell function.

Purpose of the Study:

  • To investigate the role of pain in regulating hair follicle stem cell (HFSC) activity.
  • To understand the mechanisms by which pain influences the HFSC niche.

Main Methods:

  • Utilized genetic mouse models to study pain signaling and HFSC behavior.
  • Employed advanced imaging techniques to visualize the HFSC niche.
  • Performed molecular analyses to identify signaling pathways involved.

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Development of Recombinant Proteins to Treat Chronic Pain
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Development of Recombinant Proteins to Treat Chronic Pain

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Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli
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Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

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Related Experiment Videos

Last Updated: Jun 8, 2025

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
09:31

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Published on: March 30, 2018

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Development of Recombinant Proteins to Treat Chronic Pain
10:37

Development of Recombinant Proteins to Treat Chronic Pain

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Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli
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Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

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Main Results:

  • Demonstrated that pain sensation can directly activate HFSCs.
  • Identified specific components of the HFSC niche that are modulated by pain.
  • Showcased a functional link between pain pathways and stem cell activation.

Conclusions:

  • Pain serves a dual role, encompassing sensory perception and the regulation of tissue repair processes.
  • Pain-induced modulation of the HFSC niche is a key mechanism controlling stem cell activation.
  • These findings open new avenues for understanding stem cell behavior in response to injury and inflammation.