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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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Extracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota
Qing Lin1,2, Xinchen Ouyang1, Qi Pan1
1College of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, China.
Planta Medica
|November 5, 2024
Summary
Drynariae Rhizoma effectively promotes bone formation in ovariectomized rats by positively influencing gut microbiota composition and function. This traditional herb shows promise for treating bone diseases by modulating microbial richness and specific bacterial genera.
Area of Science:
- Pharmacology
- Microbiology
- Bone Biology
Background:
- Drynariae Rhizoma is a traditional Chinese medicine used for bone diseases.
- Its precise mechanisms, particularly its interaction with the gut microbiome, remain unclear.
Purpose of the Study:
- To investigate the effects of Drynariae Rhizoma on bone health in an ovariectomized rat model.
- To explore the correlation between Drynariae Rhizoma treatment and changes in the gut microbiome.
Main Methods:
- An ovariectomized rat model was established and treated with varying doses of Drynariae Rhizoma for 12 weeks.
- Bone microstructure, bone formation markers, gut microbial composition, and serum short-chain fatty acids were analyzed.
Main Results:
- Drynariae Rhizoma treatment alleviated body weight gain and improved bone microstructure in ovariectomized rats.
- Significant increases in bone formation-related factors were observed, with the highest dose showing the most pronounced effect.
- Gut microbiome analysis revealed altered microbial richness and enrichment of specific genera (e.g., Ruminiclostridium) positively correlated with bone formation markers.
- CMP-legionaminate biosynthesis I pathway and serum short-chain fatty acids were identified as potentially regulated by Drynariae Rhizoma.
Conclusions:
- Drynariae Rhizoma demonstrates therapeutic potential for bone diseases by promoting bone formation in ovariectomized rats.
- The observed bone-protective effects are closely linked to the modulation of gut microbiota structure and function.
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