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Plant Tissue Culture

Plant tissue culture is widely used in both primary and applied science. Applications range from plant development studies to functional gene studies, crop improvement, commercial micropropagation, virus elimination, and conservation of rare species.

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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread.

Elliot Jang1, Kevt'her Hoxha1, Damian Mozier1

  • 1Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 5, 2024
PubMed
Summary

A novel tau antibody (mTau8) effectively reduces tau pathology spread in Alzheimer's disease models by binding to endogenous tau and inhibiting seed elongation, offering new insights into tau immunotherapy mechanisms.

Keywords:
human tau seedsimmunotherapymouse taumouse tau antibodytautau spreading

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Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Tau pathology transmission is a key mechanism in neurodegenerative diseases like Alzheimer's disease (AD).
  • Tau immunotherapies targeting pathological tau show promise, with several agents in clinical trials.
  • Antibodies are thought to inhibit tau seed internalization or elongation.

Purpose of the Study:

  • To investigate the mechanism of tau antibody inhibition of pathological tau spread.
  • To evaluate the efficacy of a mouse tau-specific antibody (mTau8) in models of tauopathy.

Main Methods:

  • Immunotherapy studies using primary mouse neurons and wild-type female mice.
  • Seeding models with AD patient-derived tau to induce pathology.
  • Evaluating the effect of mTau8, which does not interact with AD-tau seeds.

Main Results:

  • mTau8 demonstrated blood-brain barrier penetration comparable to other antibodies.
  • mTau8 significantly reduced AD-tau-seeded tau pathology in vitro and in vivo.
  • Data suggest mTau8 binds endogenous intraneuronal mouse tau, inhibiting internalized seed elongation.

Conclusions:

  • mTau8 effectively inhibits tau pathology spread by targeting endogenous tau.
  • Findings elucidate a potential mechanism for antibody-based tauopathy therapies.
  • This study provides valuable insights for developing novel treatments for tauopathies.