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Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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  1. Home
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. A Primer On The Pleiotropic Endocrine Fibroblast Growth Factor Fgf19/fgf15.

A primer on the pleiotropic endocrine fibroblast growth factor FGF19/FGF15.

Agathe Bouju1, Roel Nusse2, Peng V Wu3

  • 1Department of Developmental Biology, Howard Hughes Medical Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA; Sorbonne University, Paris, France.

Differentiation; Research in Biological Diversity
|November 5, 2024

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Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
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Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

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View abstract on PubMed

Summary
This summary is machine-generated.

Fibroblast Growth Factor 19 (FGF19) is an endocrine hormone regulating metabolism and development. FGF19 signaling impacts bile acid synthesis, energy balance, and cell proliferation, offering therapeutic potential.

Area of Science:

  • Endocrinology
  • Metabolic Regulation
  • Molecular Biology

Background:

  • Fibroblast Growth Factor 19 (FGF19) is a key endocrine factor regulating metabolic processes.
  • FGF19 exerts its functions by binding to β-Klotho (KLB) and FGF receptors (FGFRs).
  • The mouse ortholog, FGF15, shares functional similarities despite sequence divergence.

Purpose of the Study:

  • To review the structure, expression, and function of FGF19 and its mouse ortholog FGF15.
  • To explore the phenotypes associated with FGF19/15 deficiency and overexpression.
  • To discuss the implications of FGF19 signaling in human diseases and therapeutic strategies.

Main Methods:

  • Literature review of gene and protein structure.
  • Analysis of phenotypes in FGF19/15 mutant and transgenic mouse models.
Keywords:
Endocrine FGFFGF15FGF19Fibroblast growth factor

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  • Summary of clinical implications and therapeutic targeting.

    • Main Results:

    • FGF19/15 plays critical roles in bile acid synthesis, glucose/lipid metabolism, and embryonic development.
    • Mutant models reveal FGF19/15's involvement in metabolic homeostasis and cell proliferation.
    • Overexpression studies highlight potential for metabolic disease amelioration and tumorigenesis.

    Conclusions:

    • FGF19 signaling is a crucial pathway with diverse physiological roles.
    • Understanding FGF19/15 biology provides insights into metabolic disorders and cancer.
    • Targeting the FGF19 pathway holds promise for novel therapeutic interventions.