Nanoparticles for Delivering Micro and Macromolecules for the Management of Diabetic Wounds

Diabetes mellitus (DM) is a chronic metabolic disorder that affects most vital organs in the body. Approximately 463 million people were diagnosed with DM worldwide in 2019. The incidence of DM is estimated to increase by 700 million by 2045. Diabetic wounds (DWs) are among the most severe complications in people suffering from DM. Although diverse standard care treatment strategies are available for DWs, they are unsatisfactory because of the multifactorial pathophysiology of DWs. Cutting-edge nanoparticles are increasingly being used in treating DWs. In particular, few nanoparticles naturally act as ROS scavengers, promote angiogenesis, exhibit antimicrobial activity, and form the extracellular matrix, which is considered beneficial for DW healing. The current review focused on the pivotal potential of the present nanoparticles for DW healing, emphasizing and highlighting the use of the nanoparticles in delivering micro and macromolecules in tissue regeneration for DW healing and future perspectives.