Related Experiment Video

Updated: Jun 8, 2025

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

11.4K

Good metabolic control is associated with decreased circulating factor VIIa- antithrombin complexes in type 2

Joanna Gastoł1,2, Elżbieta Paszek3,4, Agata Bryk-Wiązania5,6

  • 1Metabolic Diseases and Diabetology Clinical Department, University Hospital, Kraków, Poland.

Cardiovascular Diabetology
|November 5, 2024
PubMed

Insights

In type 2 diabetes, higher activated factor VIIa-antithrombin complexes correlate with poor blood sugar and cholesterol control. Achieving treatment targets may help suppress tissue factor-induced coagulation activation.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Hematology

Background:

  • Type 2 diabetes (T2DM) is linked to a prothrombotic state, increasing cardiovascular event risk.
  • Activated factor VIIa-antithrombin (FVIIa-AT) complexes indicate tissue factor (TF) exposure and are associated with thromboembolic risk.
  • Previous research has not explored FVIIa-AT complexes in T2DM.

Purpose of the Study:

  • To investigate factors influencing FVIIa-AT complexes in T2DM patients.
  • To assess the impact of elevated FVIIa-AT complexes on the prothrombotic state in T2DM.
  • To establish the relationship between glycemic control, lipid profiles, and FVIIa-AT complexes.

Main Methods:

  • Compared FVIIa-AT complexes in 108 T2DM patients and 83 non-diabetic controls.
  • Assessed metabolic control using fasting glucose, HbA1c, albumin/creatinine ratio (ACR), and lipid levels.
  • Evaluated prothrombotic state via thrombin generation, fibrinolysis markers, and plasma fibrin clot properties.

Main Results:

  • FVIIa-AT complexes were similar between T2DM patients and controls.
  • Higher FVIIa-AT complexes in T2DM patients correlated with active smoking, insulin use, and elevated fasting glucose, HbA1c, ACR, total cholesterol, and LDL-cholesterol.
  • FVIIa-AT complexes did not associate with thrombin generation, fibrin clot properties, or fibrinolysis markers.
  • HbA1c, ACR, and total cholesterol were independently associated with FVIIa-AT complexes in T2DM.

Conclusions:

  • This study is the first to link higher FVIIa-AT complexes in T2DM to markers of dyslipidemia and glycemic control.
  • Findings suggest that TF-induced coagulation activation in T2DM may be mitigated by optimizing treatment targets.
  • Improved management of diabetes and associated metabolic factors could reduce thrombotic risk.
Abstract

Keywords:
Albumin/Creatinine ratioFVIIa-AT complexesGlycated hemoglobinType 2 diabetes

More Related Videos

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

25.7K
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

18.9K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
236
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
508
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
624