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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
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Therapeutic plasma exchange without anticoagulation: Single-center experience
Eduardo Zúñiga-Rodríguez1, Danna Peña1, Juliana Mantilla1
1Department of Nephrology, Fundación Cardio Infantil-La Cardio, Bogotá DC, Colombia.
Summary
Membrane therapeutic plasma exchange (mTPE) without anticoagulation is a safe hospital procedure for various conditions. This study found a low complication rate, supporting its use when clinically indicated.
Area of Science:
- Nephrology
- Immunology
- Hematology
Background:
- Membrane therapeutic plasma exchange (mTPE) treats autoimmune, neurological, hematological, and renal diseases.
- Limited data exists on mTPE effectiveness and safety without anticoagulants.
- This study assessed outcomes of mTPE without anticoagulation.
Purpose of the Study:
- To evaluate the safety and effectiveness of membrane therapeutic plasma exchange (mTPE) when performed without anticoagulant therapy.
- To analyze complication rates and adverse events associated with non-anticoagulated mTPE.
Main Methods:
- Retrospective cohort study utilizing registry data.
- Included adult patients undergoing mTPE without anticoagulants.
- Data collected from October 2021 to October 2022 at a single center.
Main Results:
- 46 patients received 385 mTPE treatments.
- Humoral kidney transplant rejection was the primary indication (59.2%).
- Low complication rate (1.3%) and device coagulation (2.1%), with no mortality.
Conclusions:
- Membrane therapeutic plasma exchange (mTPE) without anticoagulation is a safe hospital-based technique when indicated.
- Further protocols are needed for optimal use and monitoring of this therapy.
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