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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...

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International symposium on integrative bioinformatics 2024 - editorial.

Can Türker1, Christian Panse1, Bjorn Sommer2

  • 1Functional Genomics Center Zurich, University of Zurich/ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Journal of Integrative Bioinformatics
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Integrative bioinformatics addresses complex biological system challenges by integrating and modeling diverse data. This special issue presents key findings from the 18th International Symposium on Integrative Bioinformatics.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Systems Biology

Background:

  • Integrative bioinformatics aims to unify diverse biological data for comprehensive system analysis.
  • Challenges include data integration, alignment, modeling, and simulation for biological insights.

Discussion:

  • This special issue features six articles from the 18th International Symposium on Integrative Bioinformatics.
  • The symposium provided a platform for discussing advancements in the field.

Key Insights:

  • The presented research highlights novel approaches to data integration and modeling in biological systems.
  • Key findings contribute to a deeper understanding of complex biological processes.

Outlook:

  • Future research will likely focus on refining integrative methods for more accurate biological simulations.
  • Continued advancements in bioinformatics are crucial for tackling complex biological questions.