Indications for diagnostic whole-body iodine scan: a review of guidelines

Here, we have compiled all key statements derived from these guidelines and delved into details on which scenarios the diagnostic whole-body iodine scan (DxWBIS) might be useful.

We identified all relevant guidelines by searching the MEDLINE/PubMed databases, Google Scholar, and Ovid from 2006 onwards using keywords related to DxWBIS, RxWBIS, iodine scintigraphy, and iodine scan. We excluded case reports/series, original articles, and clinical trials while including guidelines or consensus opinions. Additionally, we reviewed existing literature to ensure no guidelines were overlooked.

Overall, 23 relevant guidelines or consensus opinions discussed their views on the role of DxWBIS. Different indications for DxWBIS have been largely discussed in the last few years. However, the role of DxWBIS has been well established after treatment with 131I, with still limited evidence in the other clinical assessments.

Most guidelines find DxWBIS appealing for higher-risk patients, particularly those with a chance of recurrence; additional well-designed studies are required to address further indications.