Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair
Zhengwei Liu1, Hui Zhang2, Jingjing Gan2
1Department of Orthopedics, Northern Jiangsu People's Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Yangzhou, 225001, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 6, 2024
Summary
Novel strontium hydrogel microparticles tagged with black phosphorus offer enhanced bone defect repair. These responsive particles, activated by near-infrared light, demonstrate potent anti-inflammatory and osteogenic effects for improved therapeutic outcomes.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Hydrogel implants are valuable for bone tissue regeneration.
- Developing functional implants with tailored structures and functions is crucial for improving therapeutic outcomes.
- Novel strategies are needed to enhance bone defect repair efficacy.
Purpose of the Study:
- To develop novel black phosphorus (BP) tagged responsive strontium (Sr) hydrogel particles for bone defect repair.
- To investigate the properties and efficacy of these microparticles in promoting bone regeneration.
- To evaluate the therapeutic potential of BP-Sr hydrogel microparticles under near-infrared irradiation.
Main Methods:
- Utilized microfluidic technology to integrate Sr, carboxymethyl chitosan, and BP into a poly(N-isopropyl acrylamide) (pNIPAM) hydrogel matrix, creating pNBCSMs.
- Investigated the volume shrinkage and Sr extrusion of pNBCSMs upon near-infrared (NIR) irradiation, leveraging BP's photothermal conversion and pNIPAM's thermosensitivity.
- Conducted in vitro and in vivo experiments to assess the biological effects and bone repair capabilities of the developed microparticles.
Main Results:
- pNBCSMs demonstrated volume shrinkage and Sr extrusion upon NIR exposure due to photothermal and thermosensitive properties.
- NIR-irradiated pNBCSMs exhibited superior anti-inflammatory, anti-apoptotic, and bacterial inhibitory effects in vitro and in vivo.
- Effective improvement in defective cranial bone repair was observed with pNBCSMs under NIR irradiation, highlighting their osteogenesis-promoting capabilities.
Conclusions:
- The developed black phosphorus-tagged responsive strontium hydrogel microparticles (pNBCSMs) show significant promise for bone defect repair.
- The combination of photothermal responsiveness and strontium release offers a multi-faceted therapeutic approach.
- pNBCSMs represent a novel and effective biomaterial for enhancing bone regeneration and addressing critical bone defects.
