Methanobrevibacter oralis: a comprehensive review
Virginie Pilliol1,2, Boualam Mahmoud Abdelwadoud1,3, Hamiech Aïcha1,3
1Aix-Marseille Université, Microbes Evolution, Phylogénie et Infection (MEPHI), Marseille, France.
Journal of Oral Microbiology
|November 6, 2024
Summary
Methanobrevibacter oralis, a dominant oral archaeon, is linked to various oral and extra-oral conditions. Further research is needed to clarify its transmission and clinical significance.
Area of Science:
- Microbiology
- Genomics
- Oral Health
Background:
- Methanobrevibacter oralis (M. oralis) is a predominant methanogenic archaeon in the human oral microbiota.
- Its presence dates back to Neanderthal populations, with increased dominance observed from the 18th century.
Purpose of the Study:
- To review current knowledge on M. oralis prevalence, oral and extra-oral associations, and symbiotic relationships.
- To highlight areas for future investigation regarding M. oralis.
Main Methods:
- Literature review summarizing existing studies on M. oralis.
- Analysis of genomic data, including draft and ancient assembled genomes.
- Review of PCR and RTQ-PCR methods for M. oralis identification and quantification.
Main Results:
- M. oralis is found in various oral sites in healthy individuals and those with oral pathologies like periodontal disease and endodontic infections.
- Draft genomes are approximately 2.08 Mb with an average GC% of 27.82%.
- M. oralis has been detected in extra-oral sites, including brain abscesses and respiratory samples, raising clinical questions.
Conclusions:
- M. oralis plays a significant role in oral microbiota and is associated with various pathologies.
- Transmission routes, such as maternal milk and breastfeeding, require further clarification.
- The clinical significance of M. oralis in both oral and extra-oral infections warrants continued investigation.
Keywords:
Methanogenabscessancient dental calculusdysbiosisendodontic infectionoral microbiotaperiodontitisMore Related Videos
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