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Polarization-insensitive optical coherence tomography using pseudo-depolarized reference light for mitigating

Maria Varaka1, Conrad W Merkle1, Lucas May1

  • 1Medical University of Vienna, Center for Medical Physics and Biomedical Engineering, Vienna, Austria.

Journal of Biomedical Optics
|November 6, 2024
PubMed
Summary

Birefringence artifacts in Optical Coherence Tomography (OCT) images degrade quality. This study introduces a simple depolarizer module to significantly reduce these artifacts, enhancing image clarity for biomedical applications.

Keywords:
birefringenceoptical coherence tomographypolarizationpolarization artifacts

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Area of Science:

  • Biomedical Optics
  • Optical Engineering

Background:

  • Optical coherence tomography (OCT) is susceptible to image artifacts caused by sample or system birefringence when using polarized light.
  • These artifacts compromise image quality and diagnostic accuracy in OCT.

Purpose of the Study:

  • To mitigate birefringence-related artifacts in OCT images.
  • To enhance image quality and diagnostic information in OCT.

Main Methods:

  • Investigated liquid crystal patterned retarders as pseudo-depolarizers in the reference arm of OCT systems.
  • Evaluated configurations in spectral-domain OCT using Michelson and Mach-Zehnder interferometers.
  • Tested performance with an achromatic quarter-wave plate to control sample polarization states.

Main Results:

  • The optimal depolarizer configuration significantly reduced cross-polarization artifacts by 3.9 dB (Michelson) and 7.0 dB (Mach-Zehnder).
  • Demonstrated substantial improvement in OCT signal magnitude and image quality in biological samples (marmot eye, mouse tail).
  • Achieved drastic elimination of birefringence-related artifacts, enhancing detected signal intensity.

Conclusions:

  • Presents a simple, cost-effective technique to mitigate OCT birefringence artifacts.
  • The method is readily implementable in existing OCT systems.
  • Improves the effectiveness of OCT imaging across various biomedical applications.