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  11. Prognostic Significance Of The Tumor Budding And Tumor-infiltrating Lymphocytes In Survival Of Hepatocellular Carcinoma Patients

Prognostic significance of the tumor budding and tumor-infiltrating lymphocytes in survival of hepatocellular carcinoma patients

Ahmed Mahran Shafiq1, Noura Ali Taha1, Amen Hamdy Zaky1

  • 1Department of Medical Oncology and Hematological Malignancies, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

International Journal of Health Sciences
|November 6, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Tumor budding (TB) is an independent prognostic factor in hepatocellular carcinoma (HCC), unlike tumor-infiltrating lymphocytes (TILs). High-grade TB correlates with poor prognosis, while TILs indicate immune response variations.

Area of Science:

  • Oncology
  • Pathology
  • Cancer Research

Background:

  • Hepatocellular carcinoma (HCC) management has advanced, yet prognostic factors remain unclear.
  • The prognostic significance of tumor budding (TB) and tumor-infiltrating lymphocytes (TILs) in HCC is largely unknown.

Purpose of the Study:

  • To investigate the prognostic value of TB and TILs in HCC patients.
  • To correlate TB and TILs with clinicopathological factors and survival outcomes.

Main Methods:

  • Analysis of 74 HCC surgical resection specimens.
  • Assessment of TB and TILs using hematoxylin-eosin staining.
  • 5-year follow-up for disease-free and overall survival (OS) rates.

Main Results:

  • High-grade TB associated with lymphovascular embolization (LVE), tumor necrosis, and HCC grade (P<0.05).
Keywords:
Hepatocellular carcinomaoverall survivaltumor buddingtumor-infiltrating lymphocytes

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  • TILs correlated with histological grade, LVE, and AFP levels (P<0.05).
  • Multivariate analysis identified TB as an independent prognostic factor for disease-free and OS, but not TILs.

    • Conclusions:

    • TB is a significant independent prognostic factor in HCC, indicating a poor prognosis.
    • TILs reflect immune response variations but are not independent prognostic factors.
    • TB is linked to aggressive tumor features like LVE and necrosis.