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NK Cell-Based Cancer Immunotherapies: Current Progress, Challenges and Emerging Opportunities

Mohammad Y Alshahrani1, Subasini Uthirapathy2, Abhinav Kumar3,4,5

  • 1Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia.

Journal of Biochemical and Molecular Toxicology
|November 6, 2024
PubMed

Insights

Natural killer (NK) cells are crucial for cancer therapy. NK cell-derived exosomes (NDEs) show promise alone or combined with other treatments to enhance immunotherapy and reduce side effects.

Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Natural killer (NK) cells are key innate immune cells with significant antitumor functions.
  • Current immunotherapies aim to enhance NK cell activity, but face challenges.
  • NK cell-derived exosomes (NDEs) present a safe and modifiable alternative for cancer treatment.

Purpose of the Study:

  • To review the antitumor potential of NK cells and NK cell-based immunotherapies.
  • To explore challenges and opportunities in NK cell transplantation and CAR NK cell therapy.
  • To highlight the potential of NDEs in cancer immunotherapy.

Main Methods:

  • Literature review of NK cell-based cancer therapies.
  • Analysis of NK cell-derived exosomes (NDEs) as therapeutic agents.
  • Exploration of combination strategies for enhanced cancer immunotherapy.

Main Results:

  • NK cells are vital for innate immunity and cancer therapy.
  • NDEs offer immune safety and modifiability for enhanced therapeutic efficacy.
  • NDEs can reprogram the tumor microenvironment and improve immunotherapy outcomes.

Conclusions:

  • NK cell-based immunotherapies, including NDEs, hold significant promise for cancer treatment.
  • NDEs can be utilized alone or in combination therapies to improve efficacy and reduce side effects.
  • Further clinical research into NDEs is warranted to expedite cancer immunotherapy.
Keywords:
CAR NK celladoptive cell transplantationcombination therapydrug resistanceexosomestumor microenvironment

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