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Spinal cord injury regenerative therapy development: integration of design of experiments

Yuji Okano1,2, Hideyuki Okano1,3, Yoshitaka Kase1,3

  • 1Division of CNS Regeneration and Drug Discovery, International Center for Brain Science (ICBS), Fujita Health University, Kutsukake-Cho, Toyoake-Shi, Aichi, Japan (Okano Y, Okano H, Kase Y).

Neural Regeneration Research
|November 6, 2024
PubMed
Abstract

No abstract available in PubMed .

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Spinal Cord Injury ll: Pathophysiology01:14

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Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

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